apologies for the extremely delayed answer. We were pointed to this post by another user who has the same problem. Please use the QSAR Toolbox Helpdesk where we guarantee answers within a day or two.
This issue (affecting functions under Profiling, Calculations and Metabolism) is most likely caused because a COM server (providing some of the Calculators and Metabolism simulators) is lacking privileges when run within IIS. What I can suggest is that you edit the Application Pool of the Toolbox WebAPI entry in IIS, changing the Process Model identity from ApplicationPoolIdentity (default) to LocalSystem and then restart the Toolbox WebAPI website.
Please let me know if you are still trying to get the WebAPI to work and I can provide you with detailed instructions.
Thank you very much for your answer - and the PM you send me. I would like to state my question here in the forum for future reference.
I tried to follow the instructions you provided but unfortunately was not able to find the option you mentioned. Is it somewhere hidden in a sub-sub menue?
I have to admit that I do have no expertise in using the IIS so a more detailed instruction on how to overcome this issue would be highly appreciated - maybe with some pictures
Thanks in advance for the efforts
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following your request and based on other people's interest, we have updated the WebAPI deployment manual. The modified part that addresses the described issue is in Section 4 (Deploying TBWSe in IIS). You may either delete the already created toolbox site and create it again following the slightly modified instructions, OR you can stop the website and go directly to Step 8 to make the suggested modification to the Application Pool.
thank you very much for your response. With the updated instructions it was easy to go along and now the system responds like it is supposed to.
Thank you very much.
Thank you for the effort to update the guidance. As the original poster, I can confirm that the API is now working properly for me as well. This is excellent for connecting to external tools.